The animals were sacrificed after 4 hr and functional indices of ulcer activity was studied in all rats and compared with that of nonulcer induced ones. Animals were randomly divided into four groups each of 6 rats. Pdf protective effects of ginkgo biloba extract on the. Pretreatment of the ethanol induced ulcer with girinimbine reduced the no concentration in the plasma and elevated pge 2 together with a decreased level of tnf. Antiulcerogenic activities of agelanthus dodoneifolius leaf. Pretreatment with ari significantly p gastric lesions induced by ethanol and also resulted in a significant decrease in the gastric secretion, and total acidity in pylorus ligated rats. Therapeutic value of camel milk as antiulcerogenic effect. Evaluation of anti ulcer activity of ethanolic extract of. Research paper ulcer prevention effect of 3,4,5tihydroxyn0. The percentage ulcer inhibition was significantly high p rats treated with the extract when compared with the control and the effect is similar to that of rats treated with cimetidine. The present work was done to investigate the possible effects of nigella sativa oil nso on gastric secretion and ethanolinduced ulcer in rats. Same design was used for ethanol model using ethanol. Anti ulcer activity of swietenia mahagoni leaf extract in ethanol induced gastric mucosal damage in rats.
Antiulcer activity of pisonia aculeata on pylorus ligation induced gastric ulcer in rats ch. The ameliorative effect of dates phoenix dactylifera l. Therapeutic effect of momordica balsamina leaf extract on ethanolinduced gastric ulcer in wistar rats background. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. Kaempferol protects ethanolinduced gastric ulcers in mice via pro. The collected samples of raw milk were kept at room temperature 25c and examined for physiochemical parameters as well as sensory evaluation. Gastric ulceration was induced using 80% ethanol after a pilot study was done to identify which ulcer inducing agents would induce the most ulceration with minimal mortality in one hour. Ethanol induced gastric lesions cytoprotection studies.
Nazarbahjat n, kadir fa, ariffin a, abdulla ma, abdullah z, yehye wa 2016 antioxidant properties and gastroprotective effects of 2 ethylthiobenzohydrazones on ethanolinduced acute gastric mucosal lesions in rats. Pdf antiulcerogenic activity of scutia buxifolia on gastric. Seeds extract of moringa oleifera was administered in the dose of 150 and 200 mgkg orally. Girinimbine had shown suppressing effects on cox2 enzymes, but not on cox1. Gastroprotective activity of aqueous carica papaya seed. Protective effect of sucralfate against alcoholinduced gastric mucosal injury in the rat.
Biochanin a gastroprotective effects in ethanolinduced. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. It readily penetrates the gastric mucosa due to its ability to solubilize the protective mucous and expose the mucosa to the proteolytic and hydrolytic actions of hydrochloric acid and pepsin, causing damage to the membrane. Antiulcerogenic activity of commiphora caudata bark extract. The pretreatment of rats with low and high doses of c. The aim of this study was assessment the antiulcer effects of c. Effect of garlic oil on ethanol induced gastric ulcers in rats. Antioxidant properties and gastroprotective effects of 2. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Protective role of phoenix dactylifera fruit against ethanolinduced. Research article ethanolinduced gastric ulcer in male wistar. Prevention of hclethanol induced gastric mucosal injury in. Gastroprotective effect of zingerone on ethanolinduced.
This study was performed to investigate the regular treatment of oral administration of raw camel milk 5 mgkg b. Diosmin attenuates gastric histopathologic aberrations and influx of leukocytes the current study next explored whether dio can protect against the histopathologic damage associated with ethanolinduced gastric injury in rats. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, adoekiti were used. At creative biolabs, we offer ethanolinduced gastric ulcer models induced in both rats and mice. Pdf protective role of phoenix dactylifera fruit against. Alkofahi 1999 showed that all of the effective sem and tested. The gastro protective effects of cibotium barometz hair on. Anti ulcer activity of centella asiatica leaf extract against ethanol induced gastric mucosal injury in rats. Ethanolinduced rodent gastric ulcer model creative biolabs. Gastric ulcer was induced in overnight fasted rats that. Pdf antiulcerogenic effect of cuphea ignea extract. After the treatment period, rats received oral administration of 1. Gastroprotective effect of zingerone on ethanolinduced gastric. A doseeffect relation was constructed using the ethanolinduced gastric ulcer model in male wistar rats.
Protective effects of ginkgo biloba extract on the ethanolinduced gastric ulcer in rats. Daniel and his colleagues induced ulcer with ethanol in rats to. Acute exposure of the gastric mucosa of rats to ethanol can result in gastric lesions similar to those occurring in gastric ulcer. Study of the protective effects of flaxseed oil on ethanol. Amelioration of ethanolinduced gastric ulcers in rats pretreated. Pdf gastroprotective effect of zingerone on ethanol. Four groups of male sprague dawley rats each consist of 6 animals. Evaluation of gastroprotective activity of myristica fragrans on. In addition, the composition of cesb was clarified by highperformance liquid chromatography hplc. Cibotium barometz is a medical herb used traditionally in the malaysian peninsula for several ailments, including gastric ulcer. Protective effect of falcaria vulgaris extract on ethanol.
Thirty wistar rats were divided into six groups of five rats each. Asuzu2 1department of veterinary pharmacology and toxicology, university of abuja, pmb 117 abuja, nigeria. The gastric ulcer were induced in rats by administrating absolute ethanol 90%, 1ml200gm orally, after 1hour of ethanolic extract of aegle marmelos leaves and omeprazole treatment. Based on these results, a model for the pathogenesis of ethanol induced gastric lesions is proposed. Diazoxide, a katp channel opener, prevented ethanolinduced. Original article gastroprotective effect of minocycline in. Inbred matured albino wister rat of both sexes weighing 150. Diosmin protects against ethanolinduced gastric injury in. Evaluation of the antiulcer effect of aerva javanica aerial. Ethanol etoh and aspirin asp ulcer induction the ethanol induced ulcer was carried in rats by administering ethanol as described by hollander et al. Treatment and induction of gastric ulcer with hclethanol the experiment was designed having 6 groups while 6 rats were randomly allotted to each group. Gastric acid secretion was measured and ulcer was induced using ethanol and fourhour pyloric ligation.
Ethanol extract from the leaf 20 0 mgkg bodyweight of gongronema latifolium was administered to both streptozotocin induced diabetic and control groups orally for 14 days. This was associated with a reduction of mda, which was elevated by the administration of ethanol. Antiulcer activity of seeds of moringa oleifera was studied in rats in which gastric ulcers were induced by oral administration of ethanol and pylorus ligation. Ethanol is considered a risk factor for developing gastric ulcers.
Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of nonsteroidal antiinflammatory drugs. Pdf gastroprotective effects of betanin against ethanol. Antiulcer activity of pisonia aculeata on pylorus ligation. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanolinduced gastric ulcers in rats.
Rats were classified into non ovariectomized and ovariectomized negative control groups, positive control groups where ulcer was induced by 10 ml kgg1 ethanol 50% p. Gastric lesions were induced with ethanol 96% at a dose of 0. Peptic ulcers are gastrointestinal lesions that occur in the. For testing or evaluating antipeptic ulcer activity of potential drug candidates, many rodent models have been applied including nasaidsinduced gastric ulcer models, ethanolinduced gastric ulcer models and so on. Ethanolinduced gastric ulceration in rats semantic scholar. Antiulcerogenic effect of camel milk against ethanol induced. Studies on the mechanism of ethanolinduced gastric damage in. Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found. The gastroprotective potential of minocycline was assessed against ethanol 1 ml of 100% ethanol induced gastric mucosal damage by following the method of natale et al 31. In alcohol induced ulcer model, ranitidine 30mg mgkg significantly reduced the ulcer index whereas aero7d inhibit the ulcer index significantly at the doses 800, 400mg kg p rats. Evaluation of gastroprotective activity of myristica. Ethanol induced hyperemia was markedly reduced by lipoxygenaseselective inhibitors bw755c or nordihydroguaiaretic acid, or by the h 1antihistamine pyrilamine, but not by indomethacin, cimetidine, phentolamine, or methysergide. The antiulcer activity was assessed by determining and comparing the ulcer index in the test.
Original article aripiprazole an atypical antipsychotic. Effects of nigella sativa oil on gastric secretion and. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat. The effect of oral administration of raw camel milk 5 mlkg b. Girinimbine from curry leaves promotes gastro protection. Exposure of rats to ethanol resulted in gastric mucosal injury and a high index of ulcer.
Ulcer prevention effect of 3,4,5tihydroxyn02methyl1hindol. Ulcer index of extract treated rats was improved 41. As shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat. The rats were fasted for 24 hours before the oral gavage pretreatment food but not water.
The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. The stomachs were isolated, washed gently under clean. Evaluation of antiulcer activity of moringa oleifera seed extract. It is concluded that myristica fragrans showed significant protecting activity in ethanol induced ulcer. Moreover, total acidity of extract treated group 60. Mar 30, 2015 diosmin lowers ulcer index a and area of gastric lesions b in rats with ethanolinduced gastric injury. Water supplement had been removed two hours before oral pretreatment started. Thirty two adult male rats were used in this study four groups and several parameters were determined to assess any degree of protection. Antiulcerogenic activity of scutia buxifolia on gastric. Seven groups of sprague dawley sd rats were administered 10% tween 20 in the normal control and ulcer control groups, and. The ethanolic extract of commiphora caudata bark extract was evaluated for their cytoprotective activity against ethanolinduced gastric lesions in rats. Group i served as control group received saline orally. Pdf gastroprotective effects of pistacia atlantica extract on. Ethanol induced ulcer the effects of aero7d at various doses were studied in ethanol induced ulcer in rats were shown on table 2.
The effect of oq extract on gastric ulcer in rats in pylorus ligation induced and ethanol induced models was studied using single dosing 100, 200, 400. Rats were sacrificed 1 hour later with excess of ether. Group ii animals served as ulcerogenic group received ethanol orally. According to yonei and guth 1 the gastric submucosal microvascular disturbance resulting in local ische. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced by ethanol in rats. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Antiulcerogenic effect of camel milk against ethanol induced gastric ulcers in rats. The effect of nicotine on ethanolinduced gastric ulcers in rats. Effect of garlic oil on ethanol induced gastric ulcers in rats article in phytotherapy research 181.
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